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Lysyl Oxidase / LOX Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P28300 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 4015 |
|---|---|
| Other Names | Protein-lysine 6-oxidase, 1.4.3.13, Lysyl oxidase, LOX |
| Target/Specificity | Rat Lysyl Oxidase / LOX |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Lysyl Oxidase / LOX Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LOX |
|---|---|
| Function | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). |
| Cellular Location | Secreted. Secreted, extracellular space |
| Tissue Location | Heart, placenta, skeletal muscle, kidney, lung and pancreas. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
References
Haemaelaeinen E.-R.,et al.Genomics 11:508-516(1991).
Mariani T.J.,et al.Matrix 12:242-248(1992).
Kim Y.,et al.J. Biol. Chem. 270:7176-7182(1995).
Contente S.,et al.Mol. Cell. Biochem. 194:79-91(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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