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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CDC42BPB / MRCKB Antibody (Phe1665)   

CDC42BPB / MRCKB Antibody (Phe1665)

Rabbit Polyclonal Antibody

     
  • WB - CDC42BPB / MRCKB Antibody (Phe1665) ALS16388
    Western blot of MRCK (F1665) pAb in extracts from COLO cell.
  • IHC - CDC42BPB / MRCKB Antibody (Phe1665) ALS16388
    Human Kidney, Vessel: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9Y5S2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 194kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 9578
Other Names Serine/threonine-protein kinase MRCK beta, 2.7.11.1, CDC42-binding protein kinase beta, CDC42BP-beta, DMPK-like beta, Myotonic dystrophy kinase-related CDC42-binding kinase beta, MRCK beta, Myotonic dystrophy protein kinase-like beta, CDC42BPB {ECO:0000312|EMBL:AAD37506.1}
Target/Specificity Human CDC42BPB
Reconstitution & Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsCDC42BPB / MRCKB Antibody (Phe1665) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC42BPB {ECO:0000312|EMBL:AAD37506.1}
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42
Tissue Location Expressed in all tissues examined, with high levels in heart, brain, placenta and lung
Volume 50 µl
Research Areas
Citations (0)

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Background

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.

References

Moncrieff C.L.,et al.Genomics 57:297-300(1999).
Hirosawa M.,et al.DNA Res. 6:329-336(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).
Tan I.,et al.Cell 135:123-136(2008).

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$ 395.00
Cat# ALS16388
Size:
Quantity:
(40 western blots)
Availability: 5 days
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