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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BCL10 / BCL-10 Antibody (clone 151)   

BCL10 / BCL-10 Antibody (clone 151)

Mouse Monoclonal Antibody

     
  • IHC - BCL10 / BCL-10 Antibody (clone 151) ALS16405
    Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP, Flo
Primary Accession O95999
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 151
Calculated MW 26kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 8915
Other Names B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, c-E10, Mammalian CARD-containing adapter molecule E10, mE10, BCL10, CIPER, CLAP
Target/Specificity Recognizes human B-cell lymphoma/leukaemia 10 (Bcl-10), a 31kD CARD (caspase recruitment domain) containing molecule that is involved in the regulation of apoptosis.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsBCL10 / BCL-10 Antibody (clone 151) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL10
Synonyms CIPER, CLAP
Function Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Cellular Location Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts
Tissue Location Ubiquitous.
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).

References

Willis T.G.,et al.Cell 96:35-45(1999).
Koseki T.,et al.J. Biol. Chem. 274:9955-9961(1999).
Thome M.,et al.J. Biol. Chem. 274:9962-9968(1999).
Yan M.,et al.J. Biol. Chem. 274:10287-10292(1999).
Srinivasula S.M.,et al.J. Biol. Chem. 274:17946-17954(1999).

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$ 395.00
Cat# ALS16405
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