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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SCN9A / Nav1.7 Antibody (aa702-747)   

SCN9A / Nav1.7 Antibody (aa702-747)

Rabbit Polyclonal Antibody

     
  • WB - SCN9A / Nav1.7 Antibody (aa702-747) ALS16409
    Western blot analysis of Anti-SCN9A Antibody at 1:500 dilution.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q15858
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 226kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 6335
Other Names Sodium channel protein type 9 subunit alpha, Neuroendocrine sodium channel, hNE-Na, Peripheral sodium channel 1, PN1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, SCN9A, NENA
Target/Specificity Human SCN9A / Nav1.7
Reconstitution & Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsSCN9A / Nav1.7 Antibody (aa702-747) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCN9A (HGNC:10597)
Synonyms NENA
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).
Cellular Location Cell membrane; Multi- pass membrane protein. Cell projection {ECO:0000250|UniProtKB:O08562}. Note=In neurite terminals {ECO:0000250|UniProtKB:O08562}
Tissue Location Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system Isoform 2 is expressed preferentially in the dorsal root ganglion
Volume 50 µl
Research Areas
Citations (0)

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Background

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).

References

Klugbauer N.,et al.EMBO J. 14:1084-1090(1995).
Cox J.J.,et al.Nature 444:894-898(2006).
Hillier L.W.,et al.Nature 434:724-731(2005).
Raymond C.K.,et al.J. Biol. Chem. 279:46234-46241(2004).
Diss J.K.J.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16409
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