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SCN9A / Nav1.7 Antibody (aa702-747)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q15858 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 226kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 6335 |
|---|---|
| Other Names | Sodium channel protein type 9 subunit alpha, Neuroendocrine sodium channel, hNE-Na, Peripheral sodium channel 1, PN1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, SCN9A, NENA |
| Target/Specificity | Human SCN9A / Nav1.7 |
| Reconstitution & Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Precautions | SCN9A / Nav1.7 Antibody (aa702-747) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCN9A (HGNC:10597) |
|---|---|
| Synonyms | NENA |
| Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Cell projection, neuron projection {ECO:0000250|UniProtKB:O08562}. Note=In neurite terminals. {ECO:0000250|UniProtKB:O08562} |
| Tissue Location | Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Also expressed in vagus nerves within the head and neck region (PubMed:31647222). Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).
References
Klugbauer N.,et al.EMBO J. 14:1084-1090(1995).
Cox J.J.,et al.Nature 444:894-898(2006).
Hillier L.W.,et al.Nature 434:724-731(2005).
Raymond C.K.,et al.J. Biol. Chem. 279:46234-46241(2004).
Diss J.K.J.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
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