|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml), WB (1-2 µg/ml),|
|Other Names||Cysteine dioxygenase type 1, 188.8.131.52, Cysteine dioxygenase type I, CDO, CDO-I, CDO1|
|Target/Specificity||CDO1 antibody is human, mouse and rat reactive.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Cysteine Dioxygenase / CDO1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.|
|Tissue Location||Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.|
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Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
McCann K.P.,et al.Biochim. Biophys. Acta 1209:107-110(1994).
Tsuboyama-Kasaoka N.,et al.Biosci. Biotechnol. Biochem. 63:1017-1024(1999).
Ramsden D.B.,et al.Mol. Pathol. 50:269-271(1997).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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