|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)|
|Other Names||Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG, Testosterone-estrogen-binding globulin, SHBG|
|Target/Specificity||SHBG antibody is human, mouse, and rat reactive. At least three isoforms of SHBG are known to exist; this antibody will detect all three isoforms.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SHBG Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.|
|Cellular Location||Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis|
|Tissue Location||Isoform 1 and isoform 2 are present in liver and testis|
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Provided below are standard protocols that you may find useful for product applications.
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Gershagen S.,et al.Nucleic Acids Res. 17:9245-9258(1989).
Hammond G.L.,et al.Mol. Endocrinol. 3:1869-1876(1989).
Jin P.,et al.Genomics 83:566-571(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Hammond G.L.,et al.FEBS Lett. 215:100-104(1987).
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