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XRG8 / XKR8 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9H6D3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45kDa |
| Dilution | IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml) |
| Gene ID | 55113 |
|---|---|
| Other Names | XK-related protein 8, hXkr8, XK-related protein 8, processed form, XKR8, XRG8 |
| Target/Specificity | XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | XRG8 / XKR8 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | XKR8 {ECO:0000303|PubMed:23845944, ECO:0000312|HGNC:HGNC:25508} |
|---|---|
| Function | [XK-related protein 8, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:23845944). Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (By similarity). Has no effect on calcium-induced exposure of phosphatidylserine (PubMed:23845944). Promotes myoblast differentiation and survival (PubMed:28881496). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region |
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Provided below are standard protocols that you may find useful for product applications.
Background
Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.
References
Huang C.-H.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Suzuki J.,et al.Science 341:403-406(2013).
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