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SREBF2 / SREBP2 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • WB - SREBF2 / SREBP2 Antibody (Internal) ALS16434
    Western blot analysis of SREBF2 in PC-3 cell lysate with SREBF1 antibody at 1 ug/ml.
  • IF - SREBF2 / SREBP2 Antibody (Internal) ALS16434
    Immunofluorescence of SREBF2 in human spleen tissue with SREBF2 antibody at 20 ug/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q12772
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 124kDa
Dilution IF (20 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 6721
Other Names Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, SREBF2, BHLHD2, SREBP2
Target/Specificity SREBF2 antibody is human and mouse reactive. At least three isoforms of SREBF2 are known to exist. SREBF2 antibody is predicted not to cross-react with SREBF1.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSREBF2 / SREBP2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SREBF2
Synonyms BHLHD2, SREBP2
Function Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols
Tissue Location Ubiquitously expressed in adult and fetal tissues
Research Areas
Citations (0)

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Background

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.

References

Hua X.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:11603-11607(1993).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Yokoyama C.,et al.Cell 75:187-197(1993).
Hua X.,et al.J. Biol. Chem. 271:10379-10384(1996).

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$ 395.00
Cat# ALS16434
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