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>   home   >   Products   >   Primary Antibodies   >   TICRR Antibody (C-Terminus)   

TICRR Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - TICRR Antibody (C-Terminus) ALS16435
    Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - TICRR Antibody (C-Terminus) ALS16435
    Western blot analysis of TICRR in human small intestine tissue lysate with TICRR antibody at 1...
  • IF - TICRR Antibody (C-Terminus) ALS16435
    Immunofluorescence of TICRR in human small intestine tissue with TICRR antibody at 20 ug/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q7Z2Z1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 211kDa
Dilution IF (20 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 90381
Other Names Treslin, TopBP1-interacting checkpoint and replication regulator, TopBP1-interacting, replication-stimulating protein, TICRR, C15orf42
Target/Specificity TICRR antibody is human specific. At least two isoforms of TICRR are known to exist.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsTICRR Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TICRR
Synonyms C15orf42
Function Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Cellular Location Nucleus. Note=Associates with chromatin
Citations (0)

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Background

Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

References

Kumagai A.,et al.Cell 140:349-359(2010).
Zody M.C.,et al.Nature 440:671-675(2006).
Stevens M.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS16435
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