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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MFN1 Antibody (N-Terminus)   

MFN1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - MFN1 Antibody (N-Terminus) ALS16437
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - MFN1 Antibody (N-Terminus) ALS16437
    Western blot analysis of MFN1 in A431 cell lysate with MFN1 antibody at 1 ug/ml.
  • ICC - MFN1 Antibody (N-Terminus) ALS16437
    Immunocytochemistry of MFN1 in A431 cells with MFN1 antibody at 5 ug/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, E
Primary Accession Q8IWA4
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 84kDa
Dilution ICC (5 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 55669
Other Names Mitofusin-1, 3.6.5.-, Fzo homolog, Transmembrane GTPase MFN1, MFN1
Target/Specificity MFN1 antibody is human, mouse and rat reactive. MFN1 antibody is predicted to not cross-react with MFN2.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsMFN1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MFN1
Function Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.
Cellular Location Mitochondrion outer membrane; Multi- pass membrane protein
Tissue Location Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.
Research Areas
Citations (0)

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Background

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.

References

Santel A.,et al.J. Cell Sci. 114:867-874(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hales K.G.,et al.Cell 90:121-129(1997).

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$ 395.00
Cat# ALS16437
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