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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NDST2 Antibody (N-Terminus)   

NDST2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - NDST2 Antibody (N-Terminus) ALS16443
    Western blot analysis of NDST2 in A-20 cell lysate with NDST2 antibody at 1 ug/ml in (A) the...
  • IF - NDST2 Antibody (N-Terminus) ALS16443
    Immunofluorescence of NDST2 in Daudi cells with NDST2 antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P52849
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 101kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 8509
Other Names Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2, 2.8.2.8, Glucosaminyl N-deacetylase/N-sulfotransferase 2, NDST-2, N-heparan sulfate sulfotransferase 2, N-HSST 2, Heparan sulfate N-deacetylase 2, 3.-.-.-, Heparan sulfate N-sulfotransferase 2, 2.8.2.-, NDST2, HSST2
Target/Specificity NDST2 antibody is human, mouse and rat reactive. At least two isoforms of NDST2 are known to exist; this antibody will only detect the larger isoform. NDST2 antibody is predicted not to cross-react with other members of the NDST protein family.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsNDST2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NDST2
Synonyms HSST2
Function Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein
Research Areas
Citations (0)

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Background

Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.

References

Humphries D.E.,et al.Biochem. J. 332:303-307(1998).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Pikas D.S.,et al.Biochemistry 39:4552-4558(2000).
van den Born J.,et al.Glycobiology 13:1-10(2003).
Duncan M.B.,et al.Biochem. Biophys. Res. Commun. 339:1232-1237(2006).

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$ 395.00
Cat# ALS16443
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