|Application ||WB, IHC-P, Flo, Func|
|Dilution||Func, IHC-P (5 µg/ml),|
|Other Names||T-cell differentiation antigen CD6, T12, TP120, CD6, CD6|
|Target/Specificity||CD6 molecules of approximately 130 kd.|
|Reconstitution & Storage||Store at +4°C. Do not freeze. Open under aseptic conditions.|
|Precautions||CD6 Antibody (clone UMCD6/3F7B5, Azide-free) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806) Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938).|
|Tissue Location||Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Involved in cell adhesion. Binds to CD166.
Bowen M.A.,et al.J. Immunol. 158:1149-1156(1997).
Taylor T.D.,et al.Nature 440:497-500(2006).
Aruffo A.,et al.J. Exp. Med. 174:949-952(1991).
Castro M.A.,et al.J. Immunol. 178:4351-4361(2007).
Swack J.A.,et al.J. Biol. Chem. 266:7137-7143(1991).
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