ARHGEF7 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q14155 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 90kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 8874 |
---|---|
Other Names | Rho guanine nucleotide exchange factor 7, Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85, ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB |
Target/Specificity | Human ARHGEF7 |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | ARHGEF7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ARHGEF7 |
---|---|
Synonyms | COOL1, KIAA0142, P85SPR, PAK3BP, PIXB |
Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
Cellular Location | Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions |
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Background
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
References
Nagase T.,et al.DNA Res. 2:167-174(1995).
Bagrodia S.,et al.J. Biol. Chem. 273:23633-23636(1998).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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