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ARHGEF7 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - ARHGEF7 Antibody ALS16471
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • IHC - ARHGEF7 Antibody ALS16471
    Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q14155
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 90kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 8874
Other Names Rho guanine nucleotide exchange factor 7, Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85, ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Target/Specificity Human ARHGEF7
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsARHGEF7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGEF7
Synonyms COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Cellular Location Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions
Research Areas
Citations (0)
citation

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Background

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

References

Nagase T.,et al.DNA Res. 2:167-174(1995).
Bagrodia S.,et al.J. Biol. Chem. 273:23633-23636(1998).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS16471
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