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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   PTHLH / PTHRP Antibody   

PTHLH / PTHRP Antibody

Rabbit Polyclonal Antibody

     
  • WB - PTHLH / PTHRP Antibody ALS16492
    Western blot analysis of extracts of A549 cell lines, using PTHLH antibody.
  • IHC - PTHLH / PTHRP Antibody ALS16492
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P12272
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 20kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:2000),
Additional Information
Gene ID 5744
Other Names Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP, PTHrP[1-36], PTHrP[38-94], Osteostatin, PTHrP[107-139], PTHLH, PTHRP
Target/Specificity Human PTHLH / PTHRP
Reconstitution & Storage Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
PrecautionsPTHLH / PTHRP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTHLH
Synonyms PTHRP
Function Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1.
Cellular Location Cytoplasm. Nucleus. Secreted.
Tissue Location Ubiquitous. Also expressed in the mammary gland
Volume 50 µl
Research Areas
Citations (0)

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Background

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1.

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$ 395.00
Cat# ALS16492
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