GATA3 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | P23771 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 48kDa |
Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml) |
Gene ID | 2625 |
---|---|
Other Names | Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3 |
Target/Specificity | Human GATA3 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | GATA3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GATA3 |
---|---|
Function | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. |
Cellular Location | Nucleus. |
Tissue Location | T-cells and endothelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.
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