LNX1 / LNX Antibody (clone 1H9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | Q8TBB1 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 1H9 |
Calculated MW | 81kDa |
Dilution | IHC-P (10 µg/ml), WB (1:500), |
Gene ID | 84708 |
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Other Names | E3 ubiquitin-protein ligase LNX, 6.3.2.-, Ligand of Numb-protein X 1, Numb-binding protein 1, PDZ domain-containing RING finger protein 2, LNX1, LNX, PDZRN2 |
Target/Specificity | Human LNX1 / LNX |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | LNX1 / LNX Antibody (clone 1H9) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LNX1 |
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Synonyms | LNX, PDZRN2 |
Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. |
Cellular Location | Cytoplasm. |
Tissue Location | Expressed in heart, placenta, kidney, pancreas and brain. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity).
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