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LNX1 / LNX Antibody (clone 1H9)

Mouse Monoclonal Antibody

     
  • WB - LNX1 / LNX Antibody (clone 1H9) ALS16506
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LNX1...
  • IHC - LNX1 / LNX Antibody (clone 1H9) ALS16506
    Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8TBB1
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1H9
Calculated MW 81kDa
Dilution IHC-P (10 µg/ml), WB (1:500),
Additional Information
Gene ID 84708
Other Names E3 ubiquitin-protein ligase LNX, 6.3.2.-, Ligand of Numb-protein X 1, Numb-binding protein 1, PDZ domain-containing RING finger protein 2, LNX1, LNX, PDZRN2
Target/Specificity Human LNX1 / LNX
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsLNX1 / LNX Antibody (clone 1H9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LNX1
Synonyms LNX, PDZRN2
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
Cellular Location Cytoplasm.
Tissue Location Expressed in heart, placenta, kidney, pancreas and brain.
Volume 50 µl
Research Areas
Citations (0)

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Background

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity).

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$ 395.00
Cat# ALS16506
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