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CAV2 / Caveolin 2 Antibody

Goat Polyclonal Antibody

     
  • IHC - CAV2 / Caveolin 2 Antibody ALS16509
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • IHC - CAV2 / Caveolin 2 Antibody ALS16509
    Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • WB - CAV2 / Caveolin 2 Antibody ALS16509
    Anti-CAV pAb at 1:1000 dilution.
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P51636
Reactivity Human, Mouse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 18kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:2000),
Additional Information
Gene ID 858
Other Names Caveolin-2, CAV2
Target/Specificity Detects a band of approximately 20 kDa by Western blot in HaCat cell lysate and 45 kDa CAV2-GFP transfected cell lysate. This Ab does not recognize CAV1.
Reconstitution & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PrecautionsCAV2 / Caveolin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAV2
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
Cellular Location Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Tissue Location Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts
Research Areas
Citations (0)
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Background

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).

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Discontinued
Cat# ALS16509
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