|Application ||WB, IHC-P, ICC, IHC-Fr, Flo|
|Reactivity||Human, Rabbit, Monkey|
|Calculated MW||83618 Da|
|Dilution||Flo (1:100 - 1:200), IHC-Fr (1:100 - 1:200), IHC-P (10 µg/ml), WB (1:100 - 1:500),|
|Other Names||RTN1, Reticulon-1, NSP, Reticulon 1|
|Target/Specificity||Recognizes an epitope located within the region of amino acids 421-589 of the neuro-endocrine specific protein Reticulon-1A (NSP-A), which is also present in the N-terminal part of Reticulon-1B (NSP-B). In normal tissues, reacts with brain Purkinje c ...|
|Reconstitution & Storage||PBS containing 0.09% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||RTN1 / Reticulon 1 Antibody (clone RNL-3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation|
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Provided below are standard protocols that you may find useful for product applications.
May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
Roebroek A.J.M.,et al.J. Biol. Chem. 268:13439-13447(1993).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Roebroek A.J.M.,et al.Genomics 32:191-199(1996).
Hens J.,et al.Cell Tissue Res. 292:229-237(1998).
Hunter M.,et al.Biochem. Biophys. Res. Commun. 332:982-992(2005).
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