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RTN1 / Reticulon 1 Antibody (clone RNL-3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC, IHC-F, FC |
|---|---|
| Primary Accession | Q16799 |
| Other Accession | 6252 |
| Reactivity | Human, Rabbit, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | RNL-3 |
| Calculated MW | 83618 Da |
| Dilution | Flo (1:100 - 1:200), IHC-Fr (1:100 - 1:200), IHC-P (10 µg/ml), WB (1:100 - 1:500), |
| Gene ID | 6252 |
|---|---|
| Other Names | RTN1, Reticulon-1, NSP, Reticulon 1 |
| Target/Specificity | Recognizes an epitope located within the region of amino acids 421-589 of the neuro-endocrine specific protein Reticulon-1A (NSP-A), which is also present in the N-terminal part of Reticulon-1B (NSP-B). In normal tissues, reacts with brain Purkinje c ... |
| Reconstitution & Storage | PBS containing 0.09% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | RTN1 / Reticulon 1 Antibody (clone RNL-3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RTN1 |
|---|---|
| Synonyms | NSP |
| Function | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
References
Roebroek A.J.M.,et al.J. Biol. Chem. 268:13439-13447(1993).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Roebroek A.J.M.,et al.Genomics 32:191-199(1996).
Hens J.,et al.Cell Tissue Res. 292:229-237(1998).
Hunter M.,et al.Biochem. Biophys. Res. Commun. 332:982-992(2005).
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