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GABRB3 Antibody (clone S87-25)

Mouse Monoclonal Antibody

     
  • IHC - GABRB3 Antibody (clone S87-25) ALS16526
    IHC analysis of GABA(A)R Beta 3 in frozen sections of mouse brain extract using GABRB3 antibody.
  • IHC - GABRB3 Antibody (clone S87-25) ALS16526
    Anti-GABRB3 antibody IHC staining of human brain, cerebellum, purkinje.
  • IHC - GABRB3 Antibody (clone S87-25) ALS16526
    Anti-GABRB3 antibody IHC staining of human kidney.
  • IHC-P - GABRB3 Antibody (clone S87-25) ALS16526
    Western blot analysis of GABA(A)R Beta3 in rat brain membrane lysates using a 1:1000 dilution of...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession P28472
Other Accession 2562
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names S87-25
Calculated MW 54116 Da
Dilution IHC-P (5 µg/ml),
Additional Information
Gene ID 2562
Other Names GABRB3, Cleft palate 1, Cp1, GABAA receptor beta-3 subunit, GABA(A) receptor, beta 3, ECA5, GABA A receptor beta 3
Target/Specificity ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or -Beta 1.
Reconstitution & Storage PBS pH7.4, 50% glycerol and 0.09% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsGABRB3 Antibody (clone S87-25) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GABRB3
Function Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P63079}
Research Areas
Citations (0)

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Background

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.

References

Wagstaff J.,et al.Genomics 11:1071-1078(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kirkness E.F.,et al.J. Biol. Chem. 268:4420-4428(1993).

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$ 395.00
Cat# ALS16526
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