|Application ||IHC-P, E|
|Calculated MW||267009 Da|
|Dilution||IHC-P (5 µg/ml),|
|Other Names||F8, AHF, Antihemophilic factor, Coagulation factor VIIIc, Coagulation factor VIII, DXS1253E, Factor VIII F8B, FVIII, HEMA, F8B, Factor VIII, Procoagulant component, F8C|
|Target/Specificity||Reacts with Factor VIIIc.|
|Reconstitution & Storage||0.01 M HEPES, 0.1 M sodium chloride, pH 7.2, 50% glycerol. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||F8 / FVIII / Factor VIII Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.|
|Cellular Location||Secreted, extracellular space.|
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Provided below are standard protocols that you may find useful for product applications.
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
Truett M.A.,et al.DNA 4:333-349(1985).
Wood W.I.,et al.Nature 312:330-337(1984).
Levinson B.,et al.Genomics 14:585-589(1992).
Toole J.J.,et al.Nature 312:342-347(1984).
Gitschier J.,et al.Hum. Mol. Genet. 1:199-200(1992).
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