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PDX1 Antibody (aa27-76)

Rabbit Polyclonal Antibody

     
  • IHC - PDX1 Antibody (aa27-76) ALS16538
    Anti-PDX1 / IPF1 antibody IHC staining of human brain, cerebellum.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P52945
Other Accession 3651
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 30771 Da
Dilution ELISA (1:40000), IHC-P (20 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 3651
Other Names PDX1, Glucose-sensitive factor, Insulin upstream factor 1, IPF1, Insulin promoter factor 1, IPF-1, IUF-1, STF-1, GSF, IDX-1, Islet/duodenum homeobox-1, IUF1, MODY4, PDX-1
Target/Specificity PDX1 Antibody detects endogenous levels of total PDX1 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsPDX1 Antibody (aa27-76) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDX1
Synonyms IPF1, STF1
Function Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
Cellular Location Nucleus. Cytoplasm, cytosol.
Tissue Location Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells)
Volume 50 µl
Research Areas
Citations (0)

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Background

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

References

Stoffel M.,et al.Genomics 28:125-126(1995).
Inoue H.,et al.Diabetes 45:789-794(1996).
Hiroshi I.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
Marshak S.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Hara M.,et al.Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16538
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