|Application ||WB, IHC-P, E|
|Calculated MW||56278 Da|
|Dilution||ELISA (1:1000), IHC-P (20 µg/ml), WB (1:500 - 1:1000),|
|Other Names||CYP2B6, CPB6, CYP2B, CYP2B7P, EFVM, CYP2B7, Cytochrome p450 IIb6, p450, CYPIIB6, Cytochrome P450 2B6, Cytochrome P450 IIB1, IIB1|
|Target/Specificity||Cytochrome P450 2B6 Antibody detects endogenous levels of total Cytochrome P450 2B6 protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||CYP2B6 Antibody (aa241-290) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Expressed in liver, lung and heart right ventricle.|
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Provided below are standard protocols that you may find useful for product applications.
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Yamano S.,et al.Biochemistry 28:7340-7348(1989).
Zhuge J.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Miles J.S.,et al.Nucleic Acids Res. 17:8241-8255(1989).
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