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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTPRN2 / Phogrin Antibody (aa206-255)   

PTPRN2 / Phogrin Antibody (aa206-255)

Rabbit Polyclonal Antibody

     
  • IHC - PTPRN2 / Phogrin Antibody (aa206-255) ALS16546
    Anti-PTPRN2 / Phogrin antibody IHC staining of human pancreas, islet.
  • WB - PTPRN2 / Phogrin Antibody (aa206-255) ALS16546
    Western blot of extracts from NIH-3T3 cells, using PTPRN2 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q92932
Other Accession 5799
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 111271 Da
Dilution ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 5799
Other Names PTPRN2, ICAAR, Ia-2 beta, IA-2beta, PTPRP, R-PTP-N2, Phogrin, Ptp-np, IAR, KIAA0387, PTP NE-6, Tyrosine phosphatase IA-2 beta
Target/Specificity PTPRN2 Antibody detects endogenous levels of total PTPRN2 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsPTPRN2 / Phogrin Antibody (aa206-255) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPRN2
Synonyms KIAA0387
Function Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550).
Cellular Location Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P80560}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P80560}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Note=Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity) Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin- dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity) {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475}
Tissue Location Highest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal chord (PubMed:8798755)
Volume 50 µl
Research Areas
Citations (0)

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Background

Implicated in development of nervous system and pancreatic endocrine cells.

References

Kawasaki E.,et al.Biochem. Biophys. Res. Commun. 227:440-447(1996).
Smith P.D.,et al.Biochem. Biophys. Res. Commun. 229:402-411(1996).
Cui L.,et al.J. Biol. Chem. 271:24817-24823(1996).
Jiang S.,et al.Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 4:141-150(1997).

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$ 395.00
Cat# ALS16546
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