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CYSLTR1 / CYSLT1 Antibody (aa131-180)

Rabbit Polyclonal Antibody

     
  • IHC - CYSLTR1 / CYSLT1 Antibody (aa131-180) ALS16549
    Anti-CYSLTR1 / CYSLT1 antibody IHC staining of human heart.
  • IF - CYSLTR1 / CYSLT1 Antibody (aa131-180) ALS16549
    Immunofluorescence of COS7 cells, using CYSLTR1 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9Y271
Other Accession 10800
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 38541 Da
Dilution ELISA (1:5000), IF (1:100 - 1:500), IHC-P (20 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 10800
Other Names CYSLTR1, Cys-LT1 receptor, CysLT(1), Cys-leukotriene-1 receptor, CYSLT1, CYSLT1R, CYSLTR, HG55, LTD4 receptor, HMTMF81, Cysteinyl lt1 receptor
Target/Specificity CYSLTR1 Antibody detects endogenous levels of total CYSLTR1 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsCYSLTR1 / CYSLT1 Antibody (aa131-180) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYSLTR1
Synonyms CYSLT1
Function Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

References

Lynch K.R.,et al.Nature 399:789-793(1999).
Sarau H.M.,et al.Mol. Pharmacol. 56:657-663(1999).
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).

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$ 395.00
Cat# ALS16549
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