|Application ||WB, IHC-P, IF, E|
|Calculated MW||55784 Da|
|Dilution||ELISA (1:1000), IF (1:100 - 1:500), IHC-P (20 µg/ml), WB (1:500 - 1:1000),|
|Other Names||HRH1, H1 histamine receptor, H1 receptor, Histamine 1 receptor, Histamine H1 receptor, H1-R, H1R, Histamine H(1) receptor, Histamine receptor H1, HisH1|
|Target/Specificity||HRH1 Antibody detects endogenous levels of total HRH1 protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||HRH1 / Histamine H1 Receptor Antibody (aa141-190) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
de Backer M.D.,et al.Biochem. Biophys. Res. Commun. 197:1601-1608(1993).
Fukui K.,et al.Biochem. Biophys. Res. Commun. 201:894-901(1994).
Moguilevsky N.,et al.Eur. J. Biochem. 224:489-495(1994).
Rae J.L.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Kitano T.,et al.Mol. Biol. Evol. 21:936-944(2004).
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