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KLKB1 / Plasma Kallikrein Antibody (aa341-390)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P03952 |
| Other Accession | 3818 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 71343 Da |
| Dilution | ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 3818 |
|---|---|
| Other Names | KLKB1, Fletcher factor deficiency, Fletcher factor, Kininogenin, Plasma kallikrein, PKK deficiency, Plasma kallikrein heavy chain, PPK, Prekallikrein deficiency, Plasma kallikrein light chain, Plasma prekallikrein, Kallikrein 3 |
| Target/Specificity | KLKB1 (heavy chain,Cleaved-Arg390) Antibody detects endogenous levels of fragment of activated KLKB1 resulting from cleavage adjacent to Arg390. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | KLKB1 / Plasma Kallikrein Antibody (aa341-390) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLKB1 |
|---|---|
| Synonyms | KLK3 |
| Function | Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin- angiotensin system by converting prorenin into renin. |
| Cellular Location | Secreted. |
| Tissue Location | Found in plasma (at protein level). |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
References
Chung D.W.,et al.Biochemistry 25:2410-2417(1986).
Yu H.,et al.Genomics 69:225-234(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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