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LP-PLA2 / PLA2G7 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q13093 |
| Other Accession | 7941 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 50077 Da |
| Dilution | IHC-P (1:100), WB (1:1000 - 1:4000), |
| Gene ID | 7941 |
|---|---|
| Other Names | PLA2G7, GVIIA-PLA2, PAF acetylhydrolase, PAFAD, PAF 2-acylhydrolase, PAFAH, LDL-PLA(2), LP-PLA2, Group-VIIA phospholipase A2, LDL-PLA2 |
| Target/Specificity | This Polyclonal antibody is directed against human PAF Acetylhydrolase protein. The product was purified from serum by protein A chromatography. Expect reactivity with human PAF Acetylhydrolase. Cross-reactivity with PAF Acetylhydrolase from other so ... |
| Reconstitution & Storage | PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year. |
| Precautions | LP-PLA2 / PLA2G7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLA2G7 |
|---|---|
| Synonyms | PAFAH |
| Function | Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:7700381, PubMed:8624782, PubMed:2040620, PubMed:16371369, PubMed:17090529, PubMed:10066756). At the lipid- aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:2040620, PubMed:10504265). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl- 2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10504265, PubMed:10066756, PubMed:7592717, PubMed:11590221, PubMed:7700381, PubMed:18434304, PubMed:16371369, PubMed:8675689, PubMed:8624782). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (PubMed:2040620, PubMed:7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369). |
| Cellular Location | Secreted, extracellular space Note=Associates with both LDL and HDL particles in plasma (PubMed:11590221, PubMed:12821559, PubMed:18434304, PubMed:10066756) Mainly associates with pro-inflammatory electronegative LDL particles (PubMed:12821559). |
| Tissue Location | Plasma (PubMed:11590221, PubMed:12821559). Secreted by macrophages (at protein level) (PubMed:11590221) |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
References
Tjoelker L.W.,et al.Nature 374:549-553(1995).
Tew D.G.,et al.Arterioscler. Thromb. Vasc. Biol. 16:591-599(1996).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Tjoelker L.W.,et al.J. Biol. Chem. 270:25481-25487(1995).
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