|Application ||WB, IHC-P|
|Calculated MW||18099 Da|
|Dilution||IHC-P (10 µg/ml), WB (1:2000),|
|Other Names||JCHAIN, IGCJ, Immunoglobulin J chain, IGJ, IgJ chain, JCH|
|Reconstitution & Storage||PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.|
|Precautions||JCHAIN / Ig J Chain Antibody (clone 3H7) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.|
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Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mole J.E.,et al.Biochemistry 16:3507-3513(1977).
Max E.E.,et al.J. Exp. Med. 161:832-849(1985).
Frutiger S.,et al.Biochemistry 31:12643-12647(1992).
Kristiansen T.Z.,et al.Mol. Cell. Proteomics 3:715-728(2004).
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