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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   JCHAIN / Ig J Chain Antibody (clone 3H7)   

JCHAIN / Ig J Chain Antibody (clone 3H7)

Mouse Monoclonal Antibody

  • IHC - JCHAIN / Ig J Chain Antibody (clone 3H7) ALS16557
    Anti-IGJ antibody IHC staining of human breast.
  • WB - JCHAIN / Ig J Chain Antibody (clone 3H7) ALS16557
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IGJ...
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01591
Other Accession 3512
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 3H7
Dilution IHC-P (10 µg/ml), WB (1:2000),
Additional Information
Other Names JCHAIN, IGCJ, Immunoglobulin J chain, IGJ, IgJ chain, JCH
Target/Specificity Human IGJ
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsJCHAIN / Ig J Chain Antibody (clone 3H7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JCHAIN (HGNC:5713)
Synonyms IGCJ, IGJ
Function Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Cellular Location Secreted {ECO:0000250|UniProtKB:P01592}. EMBL; AK312014; BAG34952.1; -; mRNA EMBL; M12759; AAA58902.1; -; Genomic_DNA EMBL; M12378; AAA58902.1; JOINED; Genomic_DNA CCDS; CCDS3545.1; - PIR; A01859; JIHU RefSeq; NP_653247.1; NM_144646.3 RefSeq; XP_006714274.1; XM_006714211.2 RefSeq; XP_006714275.1; XM_006714212.2 RefSeq; XP_011530227.1; XM_011531925.1 RefSeq; XP_011530228.1; XM_011531926.1 UniGene; Hs.643431; - ProteinModelPortal; P01591; - BioGrid; 109732; 19 IntAct; P01591; 4 STRING; 9606.ENSP00000254801; - iPTMnet; P01591; - PhosphoSitePlus; P01591; - UniCarbKB; P01591; - BioMuta; IGJ; - SWISS-2DPAGE; P01591; - EPD; P01591; - MaxQB; P01591; - PaxDb; P01591; - PeptideAtlas; P01591; - PRIDE; P01591; - Ensembl; ENST00000254801; ENSP00000254801; ENSG00000132465 Ensembl; ENST00000510437; ENSP00000426687; ENSG00000132465 Ensembl; ENST00000543780; ENSP00000440066; ENSG00000132465 GeneID; 3512; - KEGG; hsa:3512; - UCSC; uc003hfn.5; human CTD; 3512; - DisGeNET; 3512; - GeneCards; JCHAIN; - HGNC; HGNC:5713; JCHAIN HPA; CAB034436; - HPA; HPA044132; - MIM; 147790; gene neXtProt; NX_P01591; - OpenTargets; ENSG00000132465; - PharmGKB; PA29733; - eggNOG; ENOG410IYAZ; Eukaryota eggNOG; ENOG410YX96; LUCA GeneTree; ENSGT00390000012791; - HOGENOM; HOG000113012; - HOVERGEN; HBG006138; - InParanoid; P01591; - OMA; KCYTNRV; - OrthoDB; EOG091G0RP0; - PhylomeDB; P01591; - TreeFam; TF335878; - BioCyc; ZFISH:ENSG00000132465-MONOMER; - Reactome; R-HSA-2168880; Scavenging of heme from plasma ChiTaRS; IGJ; human GeneWiki; IGJ; - GenomeRNAi; 3512; - PRO; PR:P01591; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000132465; - CleanEx; HS_IGJ; - ExpressionAtlas; P01591; baseline and differential Genevisible; P01591; HS GO; GO:0072562; C:blood microparticle; IDA:UniProtKB GO; GO:0071750; C:dimeric IgA immunoglobulin complex; IMP:UniProtKB GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB GO; GO:0005576; C:extracellular region; NAS:UniProtKB GO; GO:0005615; C:extracellular space; IDA:UniProtKB GO; GO:0071748; C:monomeric IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0071756; C:pentameric IgM immunoglobulin complex; IDA:UniProtKB GO; GO:0071752; C:secretory dimeric IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0071751; C:secretory IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0003823; F:antigen binding; NAS:UniProtKB GO; GO:0019862; F:IgA binding; IMP:UniProtKB GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB GO; GO:0002250; P:adaptive immune response; IDA:UniProtKB GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB GO; GO:0003094; P:glomerular filtration; IMP:UniProtKB GO; GO:0006955; P:immune response; NAS:UniProtKB GO; GO:0045087; P:innate immune response; IDA:UniProtKB GO; GO:0032461; P:positive regulation of protein oligomerization; IMP:UniProtKB GO; GO:0060267; P:positive regulation of respiratory burst; IDA:UniProtKB GO; GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome GO; GO:0001895; P:retina homeostasis; IEP:UniProtKB InterPro; IPR024110; Ig_J PANTHER; PTHR10070; PTHR10070; 1 Pfam; PF15097; Ig_J_chain; 1 ProDom; PD021296; PD021296; 1 1: Evidence at protein level; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal SIGNAL 1 22 CHAIN 23 159 Immunoglobulin J chain /FTId=PRO_0000084174 MOD_RES 23 23 Pyrrolidone carboxylic acid CARBOHYD 71 71 N-linked (GlcNAc...) (complex) /FTId=CAR_000167 DISULFID 35 123 DISULFID 37 37 Interchain (with heavy chain) DISULFID 91 91 Interchain (with heavy chain) DISULFID 94 114 DISULFID 131 156 SEQUENCE 159 AA; 18099 MW; B7835C02CCC0CB05 CRC64; MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD
Volume 50 µl
Research Areas
Citations (0)

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Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.


Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mole J.E.,et al.Biochemistry 16:3507-3513(1977).
Max E.E.,et al.J. Exp. Med. 161:832-849(1985).
Frutiger S.,et al.Biochemistry 31:12643-12647(1992).
Kristiansen T.Z.,et al.Mol. Cell. Proteomics 3:715-728(2004).

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$ 395.00
Cat# ALS16557
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