|Application ||WB, IHC-P, E|
|Calculated MW||1519175 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||MUC16, CA125 ovarian cancer antigen, CA125, CA-125, MUC-16, Mucin-16|
|Target/Specificity||Recognizes the ovarian cancer mucin CA125 (also known as MUC16). CA125 consists of a short cytoplasmic tail, a transmembrane domain and an exceptionally large glycosylated extracellular domain. The extracellular domain is dominated by a large number ...|
|Reconstitution & Storage||Tris buffered saline, 0.09% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MUC16 / CA125 Antibody (Extracellular Domain, clone X325) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain|
|Tissue Location||Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas|
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Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
O'Brien T.J.,et al.Tumor Biol. 23:154-169(2002).
O'Brien T.J.,et al.Tumor Biol. 22:348-366(2001).
Yin B.W.T.,et al.J. Biol. Chem. 276:27371-27375(2001).
Lloyd K.O.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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