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DCP2 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - DCP2 Antibody ALS16562
    Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - DCP2 Antibody ALS16562
    Western Blot analysis of Jurkat lysates with anti-DCP2 antibody
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8IU60
Other Accession 167227
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 48457 Da
Dilution ELISA (1:1000 - 1:5000), IHC-P (1:100), WB (1:200 - 1:500),
Additional Information
Gene ID 167227
Other Names DCP2, MRNA-decapping enzyme 2, Nudix motif 20, NUDT20, HDpc, M7GpppN-mRNA hydrolase
Target/Specificity Not yet tested in other species.
Reconstitution & Storage Supplied as a liquid PBS, pH 7.4, with 0.02% Sodium Azide. Store at -20°C for up to one year.
PrecautionsDCP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCP2
Synonyms NUDT20
Function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).
Cellular Location Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322).
Tissue Location Expressed in brain and testis. Not detected in heart (at protein level).
Volume 50 µl
Citations (0)

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Background

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.

References

Lykke-Andersen J.,et al.Mol. Cell. Biol. 22:8114-8121(2002).
Wang Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12663-12668(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
van Dijk E.,et al.EMBO J. 21:6915-6924(2002).

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$ 395.00
Cat# ALS16562
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