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DCP2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8IU60 |
| Other Accession | 167227 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 48423 Da |
| Dilution | ELISA (1:1000 - 1:5000), IHC-P (1:100), WB (1:200 - 1:500), |
| Gene ID | 167227 |
|---|---|
| Other Names | DCP2, MRNA-decapping enzyme 2, Nudix motif 20, NUDT20, HDpc, M7GpppN-mRNA hydrolase |
| Target/Specificity | Not yet tested in other species. |
| Reconstitution & Storage | Supplied as a liquid PBS, pH 7.4, with 0.02% Sodium Azide. Store at -20°C for up to one year. |
| Precautions | DCP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DCP2 |
|---|---|
| Synonyms | NUDT20 |
| Function | Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O- dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). |
| Cellular Location | Cytoplasm, P-body. Nucleus Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322) |
| Tissue Location | Expressed in brain and testis. Not detected in heart (at protein level). |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.
References
Lykke-Andersen J.,et al.Mol. Cell. Biol. 22:8114-8121(2002).
Wang Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12663-12668(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
van Dijk E.,et al.EMBO J. 21:6915-6924(2002).
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