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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CALR / Calreticulin Antibody   

CALR / Calreticulin Antibody

Rabbit Polyclonal Antibody

     
  • IHC - CALR / Calreticulin Antibody ALS16566
    Anti-CALR / Calreticulin antibody IHC staining of human kidney.
  • IF - CALR / Calreticulin Antibody ALS16566
    Calreticulin, Mouse back skin.
  • WB - CALR / Calreticulin Antibody ALS16566
    Western blot analysis of Calreticulin in various cell lysates, using a 1:1000 dilution of...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, IP
Primary Accession P27797
Other Accession 811
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Sheep, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 48142 Da
Dilution IHC-P (1:100), WB (1:5000 - 1:10000), WB (1:5000 - 1:10000),
Additional Information
Gene ID 811
Other Names CALR, Calregulin, CC1qR, CRP55, CRT, CRTC, ERp60, Grp60, RO, SSA, Calreticulin, HACBP
Target/Specificity Detects ~63 kD protein.
Reconstitution & Storage Antiserum. Store at -20°C.
PrecautionsCALR / Calreticulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CALR
Synonyms CRTC
Function Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
Cellular Location Endoplasmic reticulum lumen Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P28491}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). Associated with the lytic granules in the cytolytic T-lymphocytes.
Volume 50 µl
Research Areas
Citations (0)

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Background

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

References

McCauliffe D.P.,et al.J. Clin. Invest. 85:1379-1391(1990).
Rokeach L.A.,et al.J. Immunol. 147:3031-3039(1991).
McCauliffe D.P.,et al.J. Biol. Chem. 267:2557-2562(1992).
Liu J.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).

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$ 395.00
Cat# ALS16566
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