|Reactivity||Human, Mouse, Rat|
|Calculated MW||58536 Da|
|Dilution||IHC-P (5 µg/ml),|
|Other Names||DNTT, DNA nucleotidylexotransferase, TDT, Terminal addition enzyme, Terminal transferase|
|Reconstitution & Storage||PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.|
|Precautions||DNTT / TdT Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Peterson R.C.,et al.J. Biol. Chem. 260:10495-10502(1985).
Riley L.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:2489-2493(1988).
Ibe S.,et al.Genes Cells 6:815-824(2001).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
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