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A1CF / ACF Antibody

Rabbit Polyclonal Antibody

     
  • IHC - A1CF / ACF Antibody ALS16569
    Anti-A1CF / ACF antibody IHC staining of human spleen.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9NQ94
Other Accession 29974
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 65202 Da
Dilution ELISA (1:20000 - 1:80000), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 29974
Other Names A1CF, ACF65, ACF64, APOBEC-1 stimulating protein, APOBEC1 complementation factor, APOBEC1CF, ACF, Apo-B RNA editing protein, APOBEC1-stimulating protein, RP11-564C4.2, ASP
Reconstitution & Storage PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.
PrecautionsA1CF / ACF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name A1CF
Synonyms ACF, ASP {ECO:0000312|EMBL:CAB94754.1}
Function Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
Cellular Location Nucleus. Endoplasmic reticulum. Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity) Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.
Tissue Location Widely expressed with highest levels in brain, liver, pancreas, colon and spleen.
Volume 50 µl
Citations (0)

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Background

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

References

Lellek H.,et al.J. Biol. Chem. 275:19848-19856(2000).
Mehta A.,et al.Mol. Cell. Biol. 20:1846-1854(2000).
Sowden M.P.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).

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$ 395.00
Cat# ALS16569
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