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A1CF / ACF Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NQ94 |
| Other Accession | 29974 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65202 Da |
| Dilution | ELISA (1:20000 - 1:80000), IHC-P (5 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 29974 |
|---|---|
| Other Names | A1CF, ACF65, ACF64, APOBEC-1 stimulating protein, APOBEC1 complementation factor, APOBEC1CF, ACF, Apo-B RNA editing protein, APOBEC1-stimulating protein, RP11-564C4.2, ASP |
| Reconstitution & Storage | PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year. |
| Precautions | A1CF / ACF Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | A1CF |
|---|---|
| Synonyms | ACF, ASP {ECO:0000312|EMBL:CAB94754.1} |
| Function | Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense- mediated decay. |
| Cellular Location | Nucleus. Endoplasmic reticulum Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. |
| Tissue Location | Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
References
Lellek H.,et al.J. Biol. Chem. 275:19848-19856(2000).
Mehta A.,et al.Mol. Cell. Biol. 20:1846-1854(2000).
Sowden M.P.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
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