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MMP14 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P50281 |
| Other Accession | 4323 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 65894 Da |
| Dilution | ELISA (1:10000 - 1:40000), IHC-P (2.5 µg/ml), WB (1:200 - 1:500), |
| Gene ID | 4323 |
|---|---|
| Other Names | MMP14, Membrane type-1 MMP, MT1-MMP, MT1MMP, MT-MMP, MT-MMP 1, Matrix metalloproteinase-14, MMP-14, MMP-X1, MTMMP1 |
| Reconstitution & Storage | PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year. |
| Precautions | MMP14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MMP14 |
|---|---|
| Function | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV Forms a complex with BST2 and localizes to the cytoplasm |
| Tissue Location | Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2.
References
Sato H.,et al.Nature 370:61-65(1994).
Takino T.,et al.Gene 155:293-298(1995).
Okada A.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:2730-2734(1995).
Will H.,et al.Eur. J. Biochem. 231:602-608(1995).
Luo G.-X.,et al.Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
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