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KCNMA1 / BK Antibody (Gln770)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q12791 |
| Other Accession | 3778 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 137560 Da |
| Dilution | IHC-P (5 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 3778 |
|---|---|
| Other Names | KCNMA1, BA205K10.1, BKCA alpha subunit, BK channel, BKCA alpha, BKTM, HSlo, K(VCA)alpha, KCa1.1, Maxi-K channel HSLO, MaxiK, KCNMA, SAKCA, SLO-ALPHA, Slowpoke homolog, Stretch-activated Kca channel, Slo homolog, BK channel alpha subunit, Maxi K chann ... |
| Target/Specificity | Human KCNMA1 / BK |
| Reconstitution & Storage | PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Precautions | KCNMA1 / BK Antibody (Gln770) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNMA1 (HGNC:6284) |
|---|---|
| Synonyms | KCNMA, SLO |
| Function | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. Except in myocytes, it is almost ubiquitously expressed. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
References
Dworetzky S.I.,et al.Brain Res. Mol. Brain Res. 27:189-193(1994).
McCobb D.P.,et al.Am. J. Physiol. 269:H767-H777(1995).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Tseng-Crank J.,et al.Neuron 13:1315-1330(1994).
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