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Selenium Binding Protein 1 Antibody (clone 3D4)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q13228 |
| Other Accession | 8991 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | 3D4 |
| Calculated MW | 52391 Da |
| Dilution | IHC-P (1:150), WB (1:2000), |
| Gene ID | 8991 |
|---|---|
| Other Names | SELENBP1, HSBP, HSP56, SBP56, Selenium-binding protein 1, SBP, SP56, LPSB, Selenium binding protein 1 |
| Target/Specificity | Human SELENBP1 / SP56 |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | Selenium Binding Protein 1 Antibody (clone 3D4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SELENBP1 |
|---|---|
| Synonyms | SBP |
| Function | Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). |
| Cellular Location | Nucleus. Cytoplasm, cytosol Membrane {ECO:0000250|UniProtKB:Q8VIF7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VIF7}. Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). {ECO:0000250|UniProtKB:Q8VIF7} |
| Tissue Location | Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
References
Chang P.W.G.,et al.J. Cell. Biochem. 64:217-224(1997).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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