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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   BMPR2 Antibody (clone 1F12)   

BMPR2 Antibody (clone 1F12)

Mouse Monoclonal Antibody

     
  • IHC - BMPR2 Antibody (clone 1F12) ALS16589
    Anti-BMPR2 antibody IHC staining of human heart.
  • WB - BMPR2 Antibody (clone 1F12) ALS16589
    Western blot using BMPR2 mouse monoclonal antibody against HeLa (1), A431 (2), NIH/3T3 (3), Cos7...
  • E - BMPR2 Antibody (clone 1F12) ALS16589
    Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q13873
Other Accession 659
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 1F12
Calculated MW 115201 Da
Dilution ELISA (1:10000), IHC-P (1:50), WB (1:500 - 1:2000),
Additional Information
Gene ID 659
Other Names BMPR2, BMPR-II, BMPR-2, BMPR3, BMP type II receptor, BRK-3, PPH1, T-ALK, BMP type-2 receptor, BMR2
Target/Specificity Human BMPR-II / BMPR2
Reconstitution & Storage Ascites, 0.03% sodium azide. Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsBMPR2 Antibody (clone 1F12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMPR2
Synonyms PPH1
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in heart and liver.
Research Areas
Citations (0)

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

References

Liu F.,et al.Mol. Cell. Biol. 15:3479-3486(1995).
Rosenzweig B.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7632-7636(1995).
Nohno T.,et al.J. Biol. Chem. 270:22522-22526(1995).
Kawabata M.,et al.J. Biol. Chem. 270:5625-5630(1995).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 395.00
Cat# ALS16589
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