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CDX2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - CDX2 Antibody (C-Terminus) ALS16590
    Anti-CDX2 antibody IHC staining of human small intestine.
    detail
  • IF - CDX2 Antibody (C-Terminus) ALS16590
    Immunofluorescence of CDX2 in rat brain tissue with CDX2 antibody at 20 ug/ml
    detail
  • WB - CDX2 Antibody (C-Terminus) ALS16590
    Western blot analysis of CDX2 in mouse brain tissue lysate with CDX2 antibody at 1 µg/mL.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q99626
Other Accession 1045
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 33520 Da
Dilution IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 1045
Other Names CDX2, Caudal-type homeobox protein 2, CDX3, Homeobox protein CDX-2, Caudal type homeobox 2, CDX-3
Target/Specificity Human CDX2
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCDX2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDX2
Synonyms CDX3
Function Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P43241}.
Tissue Location Detected in small intestine, colon and pancreas.
Research Areas
Citations (0)
citation

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Background

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

References

Drummond F.J.,et al.Ann. Hum. Genet. 61:393-400(1997).
Mallo G.V.,et al.Int. J. Cancer 74:35-44(1997).
Sivagnanasundaram S.,et al.Br. J. Cancer 84:218-225(2001).
Tanizawa Y.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).

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Discontinued
Cat# ALS16590
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