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Vasohibin 1 / VASH1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - Vasohibin 1 / VASH1 Antibody (C-Terminus) ALS16593
    Anti-Vasohibin 1 / VASH1 antibody IHC staining of human prostate, ganglion.
  • IF - Vasohibin 1 / VASH1 Antibody (C-Terminus) ALS16593
    Immunofluorescence of VASH1 in mouse brain tissue with VASH1 antibody at 20 µg/mL.
  • WB - Vasohibin 1 / VASH1 Antibody (C-Terminus) ALS16593
    Western blot analysis of VASH1 in human brain tissue lysate with VASH1 antibody at 1 ug/ml in...
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q7L8A9
Other Accession 22846
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 40957 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 22846
Other Names VASH1, KIAA1036, VASH, Vasohibin 1, Vasohibin-1
Target/Specificity Human VASH1. VASH1 antibody is predicted to not cross-react with other vasohibin protein family members. At least two isoforms are known to exist; this antibody will recognize only the long isoform.
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsVasohibin 1 / VASH1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VASH1
Synonyms KIAA1036, VASH
Function Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.
Cellular Location Secreted
Tissue Location Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions
Research Areas
Citations (0)

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Background

Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.

References

Kikuno R.,et al.DNA Res. 6:197-205(1999).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Heilig R.,et al.Nature 421:601-607(2003).
Watanabe K.,et al.J. Clin. Invest. 114:898-907(2004).
Shimizu K.,et al.Biochem. Biophys. Res. Commun. 327:700-706(2005).

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$ 395.00
Cat# ALS16593
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