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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   DBP5 / SON Antibody (N-Terminus)   

DBP5 / SON Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • IHC - DBP5 / SON Antibody (N-Terminus) ALS16598
    Anti-DBP5 / SON antibody IHC staining of human small intestine.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P18583
Other Accession 6651
Reactivity Human, Mouse, Rat, Rabbit, Monkey, Bovine, Horse, Guinea Pig, Dog
Host Goat
Clonality Polyclonal
Calculated MW 263830 Da
Dilution ELISA (1:32000), IHC-P (5 µg/ml),
Additional Information
Gene ID 6651
Other Names SON, C21orf50, DBP5, DBP-5, KIAA1019, NREBP, Protein SON, Protein DBP-5, SON DNA binding protein, NRE-binding protein, SON3, BASS1
Target/Specificity Human SON. This antibody is expected to recognize reported isoforms B ( NP_115571.1) and F (NP_620305.1).
Reconstitution & Storage Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsDBP5 / SON Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SON
Synonyms C21orf50, DBP5, KIAA1019, NREBP
Function RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions.
Cellular Location Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2
Tissue Location Widely expressed, with the higher expression seen in leukocyte and heart
Research Areas
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Background

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions.

References

Reymond A.,et al.Genomics 78:46-54(2001).
Sun C.-T.,et al.J. Biol. Chem. 276:24059-24067(2001).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Hattori M.,et al.Nature 405:311-319(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16598
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