HDGFRP2 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q7Z4V5 |
Other Accession | 84717 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 74317 Da |
Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (0.5 - 1 µg/ml), |
Gene ID | 84717 |
---|---|
Other Names | HDGFRP2, HDGF-2, HDGF2, HRP-2 |
Target/Specificity | Human HDGFRP2. At least two isoforms of HDGFRP2 are known to exist; this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other HDGFRP family members |
Reconstitution & Storage | PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | HDGFRP2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HDGFL2 (HGNC:14680) |
---|---|
Function | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). |
Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q925G1} |
Tissue Location | Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples |
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Provided below are standard protocols that you may find useful for product applications.
References
Yu L.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Wu H.,et al.PLoS ONE 6:E18919-E18919(2011).
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