|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||37619 Da|
|Dilution||IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||TMEM59L, C19orf4, Transmembrane protein 59-like, BSMAP|
|Target/Specificity||Human TMEM59L / C19orf4. Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TMEM59L Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.|
|Cellular Location||Golgi apparatus membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed preferentially at high level in the brain|
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Provided below are standard protocols that you may find useful for product applications.
Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
Elson G.C.A.,et al.Biochem. Biophys. Res. Commun. 264:55-62(1999).
Ullrich S.,et al.J. Biol. Chem. 285:20664-20674(2010).
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