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C1orf187 / DRAXIN Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - C1orf187 / DRAXIN Antibody (C-Terminus) ALS16606
    Anti-C1orf187 / DRAXIN antibody IHC staining of human brain, cortex.
  • IF - C1orf187 / DRAXIN Antibody (C-Terminus) ALS16606
    Immunofluorescence of NEUCRIN in mouse brain tissue with NEUCRIN antibody at 20 µg/mL.
  • WB - C1orf187 / DRAXIN Antibody (C-Terminus) ALS16606
    Western blot analysis of Neucrin in rat cerebellum tissue lysate with Neucrin antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8NBI3
Other Accession 374946
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 38650 Da
Dilution IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 374946
Other Names DRAXIN, AGPA3119, UNQ3119, C1orf187, Neucrin
Target/Specificity Human C1orf187 / Neucrin/ Draxin. At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsC1orf187 / DRAXIN Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060}
Synonyms C1orf187
Function Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

References

Miyake A.,et al.Biochem. Biophys. Res. Commun. 390:1051-1055(2009).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Gregory S.G.,et al.Nature 441:315-321(2006).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).

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$ 395.00
Cat# ALS16606
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