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C2orf40 / ECRG4 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - C2orf40 / ECRG4 Antibody (C-Terminus) ALS16607
    Anti-C2orf40 / ECRG4 antibody IHC staining of human skeletal muscle.
    detail
  • ICC - C2orf40 / ECRG4 Antibody (C-Terminus) ALS16607
    Immunocytochemistry of ECRG4 in HeLa cells with ECRG4 antibody at 5 µg/mL.
    detail
  • WB - C2orf40 / ECRG4 Antibody (C-Terminus) ALS16607
    Western blot analysis of ECRG4 in HeLa cell lysate with ECRG4 antibody at (A) 1 and (B) 2 ug/ml.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, E
Primary Accession Q9H1Z8
Other Accession 84417
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 17183 Da
Dilution ICC (5 µg/ml), IHC-P (5 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 84417
Other Names C2orf40, ECRG4, Augurin
Target/Specificity Human C2orf40. ECRG4 antibody is predicted to not cross-react with other ECRG family members.
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsC2orf40 / ECRG4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ECRG4 (HGNC:24642)
Synonyms C2orf40
Function Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity).
Cellular Location Secreted. Cytoplasm. Apical cell membrane
Tissue Location Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level)
Research Areas
Citations (0)
citation

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Background

Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.

References

Bi M.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mirabeau O.,et al.Genome Res. 17:320-327(2007).

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Discontinued
Cat# ALS16607
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