C2orf40 / ECRG4 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC, E |
---|---|
Primary Accession | Q9H1Z8 |
Other Accession | 84417 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 17183 Da |
Dilution | ICC (5 µg/ml), IHC-P (5 µg/ml), WB (1 - 2 µg/ml), |
Gene ID | 84417 |
---|---|
Other Names | C2orf40, ECRG4, Augurin |
Target/Specificity | Human C2orf40. ECRG4 antibody is predicted to not cross-react with other ECRG family members. |
Reconstitution & Storage | PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | C2orf40 / ECRG4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ECRG4 (HGNC:24642) |
---|---|
Synonyms | C2orf40 |
Function | Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity). |
Cellular Location | Secreted. Cytoplasm. Apical cell membrane |
Tissue Location | Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.
References
Bi M.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mirabeau O.,et al.Genome Res. 17:320-327(2007).
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