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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RAPGEF3 / EPAC Antibody (N-Terminus)   

RAPGEF3 / EPAC Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - RAPGEF3 / EPAC Antibody (N-Terminus) ALS16612
    Anti-RAPGEF3 / EPAC antibody IHC staining of human skeletal muscle.
  • IF - RAPGEF3 / EPAC Antibody (N-Terminus) ALS16612
    Immunofluorescence of EPAC1 in rat brain tissue with EPAC1 antibody at 20 µg/mL.
  • WB - RAPGEF3 / EPAC Antibody (N-Terminus) ALS16612
    Western blot analysis of EPAC1 in rat skeletal muscle tissue lysate with EPAC1 antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O95398
Other Accession 10411
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 103751 Da
Dilution IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 10411
Other Names RAPGEF3, Bcm910, CAMP-GEFI, CGEF1, HSU79275, EPAC, EPAC 1, EPAC1
Target/Specificity Human RAPGEF3 / EPAC. At least two isoforms of EPAC1 are known to exist; this antibody will detect both isoforms. EPAC1 antibody is predicted to not cross-react with EPAC2.
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsRAPGEF3 / EPAC Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAPGEF3
Synonyms CGEF1, EPAC, EPAC1
Function Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin.
Cellular Location Endomembrane system
Tissue Location Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney
Research Areas
Citations (0)

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Background

Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin.

References

Kawasaki H.,et al.Science 282:2275-2279(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
de Rooij J.,et al.Nature 396:474-477(1998).

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$ 395.00
Cat# ALS16612
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