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LZTS2 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9BRK4 |
| Other Accession | 84445 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 72759 Da |
| Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml), |
| Gene ID | 84445 |
|---|---|
| Other Names | LZTS2, HLZTS2, KIAA1813, LAPSER1, RP11-108L7.8, Protein LAPSER1 |
| Target/Specificity | Human LZTS2. LZTS2 antibody is predicted to not cross-react with other LZTS family members |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | LZTS2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LZTS2 {ECO:0000255|HAMAP-Rule:MF_03026} |
|---|---|
| Function | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis |
| Tissue Location | Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
References
Nagase T.,et al.DNA Res. 8:85-95(2001).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Cabeza-Arvelaiz Y.,et al.Oncogene 20:6707-6717(2001).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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