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>   home   >   Products   >   Primary Antibodies   >   LZTS2 Antibody (N-Terminus)   

LZTS2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - LZTS2 Antibody (N-Terminus) ALS16613
    Anti-LZTS2 antibody IHC staining of human liver.
  • IF - LZTS2 Antibody (N-Terminus) ALS16613
    Immunofluorescence of LZTS2 in human kidney tissue with LZTS2 antibody at 20 µg/mL.
  • WB - LZTS2 Antibody (N-Terminus) ALS16613
    Western blot analysis of LZTS2 in human kidney tissue lysate with LZTS2 antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9BRK4
Other Accession 84445
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 72759 Da
Dilution IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 84445
Other Names LZTS2, HLZTS2, KIAA1813, LAPSER1, RP11-108L7.8, Protein LAPSER1
Target/Specificity Human LZTS2. LZTS2 antibody is predicted to not cross-react with other LZTS family members
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsLZTS2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LZTS2 {ECO:0000255|HAMAP-Rule:MF_03026}
Function Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis
Tissue Location Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
Citations (0)

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Background

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

References

Nagase T.,et al.DNA Res. 8:85-95(2001).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Cabeza-Arvelaiz Y.,et al.Oncogene 20:6707-6717(2001).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS16613
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