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KIAA0692 / ANKLE2 Antibody (Internal)

Chicken Polyclonal Antibody

     
  • IHC - KIAA0692 / ANKLE2 Antibody (Internal) ALS16618
    Anti-KIAA0692 / ANKLE2 antibody IHC staining of human skin.
  • WB - KIAA0692 / ANKLE2 Antibody (Internal) ALS16618
    Western blot analysis of ANKLE2 in SW480 cell lysate with ANKLE2 antibody at (A) 1 and (B) 2 ug/ml.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q86XL3
Other Accession 23141
Reactivity Human, Mouse, Rat
Host Chicken
Clonality Polyclonal
Isotype IgY
Calculated MW 104114 Da
Dilution IHC-P (5 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 23141
Other Names ANKLE2, KIAA0692, LEMD7, LEM domain containing 7, Lem4
Target/Specificity Human ANKLE2 / KIAA0692. Three isoforms of ANKLE2 are known to exist; this antibody will detect all three. ANKLE2 antibody is predicted to not cross-react with ANKLE2.
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKIAA0692 / ANKLE2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANKLE2
Synonyms KIAA0692, LEM4
Function Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development (PubMed:25259927).
Cellular Location Endoplasmic reticulum membrane; Single-pass type III membrane protein
Research Areas
Citations (0)

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Background

Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Cantin G.T.,et al.J. Proteome Res. 7:1346-1351(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 395.00
Cat# ALS16618
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