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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   SAMHD1 Antibody (clone 3F5)   

SAMHD1 Antibody (clone 3F5)

Mouse Monoclonal Antibody

     
  • IHC - SAMHD1 Antibody (clone 3F5) ALS16624
    Anti-SAMHD1 antibody IHC staining of human lung.
  • IF - SAMHD1 Antibody (clone 3F5) ALS16624
    Anti-SAMHD1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently...
  • WB - SAMHD1 Antibody (clone 3F5) ALS16624
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SAMHD1...
  • WB - SAMHD1 Antibody (clone 3F5) ALS16624
    Western blot of extracts (35 ug) from 9 different cell lines by using anti-SAMHD1 monoclonal...
  • FC - SAMHD1 Antibody (clone 3F5) ALS16624
    Flow cytometry of HeLa cells, using anti-SAMHD1 antibody (Red), compared to a nonspecific...
  • FC - SAMHD1 Antibody (clone 3F5) ALS16624
    Flow cytometry of Jurkat cells, using anti-SAMHD1 antibody (Red), compared to a nonspecific...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, Flo
Primary Accession Q9Y3Z3
Other Accession 25939
Reactivity Human, Mouse, Rat, Monkey, Dog
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 3F5
Calculated MW 72201 Da
Dilution Flo (1:100), IF (1:100), IHC-P (5 µg/ml), WB (1:200 - 1:500),
Additional Information
Gene ID 25939
Other Names SAMHD1, AGS5, CHBL2, DCIP, HDDC1, Monocyte protein 5, MOP-5, MOP5, SBBI88, Mg11, SAM domain and HD domain 1
Target/Specificity Human SAMHD1 / DCIP
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsSAMHD1 Antibody (clone 3F5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SAMHD1
Synonyms MOP5
Function Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
Cellular Location Nucleus
Tissue Location Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus
Research Areas
Citations (0)

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Background

Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.

References

Li N.,et al.Immunol. Lett. 74:221-224(2000).
Takayama K.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 395.00
Cat# ALS16624
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