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PDZK1 Antibody (clone AT1A2)

Mouse Monoclonal Antibody

     
  • IHC - PDZK1 Antibody (clone AT1A2) ALS16628
    Anti-PDZK1 antibody IHC staining of human kidney.
  • WB - PDZK1 Antibody (clone AT1A2) ALS16628
    Western Blot: The cell lysates of HeLa (40 ug) and 293T (40 ug) were resolved by SDS-PAGE,...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q5T2W1
Other Accession 5174
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b,k
Clone Names AT1A2
Calculated MW 57129 Da
Dilution IHC-P (10 µg/ml), WB (1:1000),
Additional Information
Gene ID 5174
Other Names PDZK1, CAP70, CLAMP, NHERF-3, PDZD1, PDZ domain containing 1, NaPi-Cap1, NHERF3
Target/Specificity Human PDZK1
Reconstitution & Storage Supplied in PBS, pH 7.4, 10% glycerol, 0.02% sodium azide. Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
PrecautionsPDZK1 Antibody (clone AT1A2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDZK1
Synonyms CAP70, NHERF3, PDZD1
Function A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
Cellular Location Membrane {ECO:0000250|UniProtKB:Q9JJ40}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes {ECO:0000250|UniProtKB:Q9JJ40}
Tissue Location Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.
Volume 50 µl
Research Areas
Citations (0)

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Background

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).

References

Kocher O.,et al.Lab. Invest. 78:117-125(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Kocher O.,et al.Lab. Invest. 79:1161-1170(1999).
Wang S.,et al.Cell 103:169-179(2000).

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$ 395.00
Cat# ALS16628
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