|Application ||WB, IHC-P, E|
|Calculated MW||53704 Da|
|Dilution||IHC-P (10 µg/ml), WB (1:1000),|
|Other Names||KRT8, CARD2, CK-8, CYK8, Cytokeratin-8, CK8, K2C8, K8, KO, Keratin-8, Type-II keratin Kb8, Cytokeratin 8, Keratin 8|
|Target/Specificity||Human KRT8 / CK8 / Cytokeratin 8|
|Reconstitution & Storage||Supplied in PBS, pH 7.4, 10% glycerol, 0.02% sodium azide. Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.|
|Precautions||KRT8 / CK8 / Cytokeratin 8 Antibody (clone AT3D11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.|
|Cellular Location||Cytoplasm. Nucleus, nucleoplasm Nucleus matrix|
|Tissue Location||Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Krauss S.,et al.Gene 86:241-249(1990).
Yamamoto R.,et al.Mol. Endocrinol. 4:370-374(1990).
Waseem A.,et al.New Biol. 2:464-478(1990).
Ku N.-O.,et al.J. Biol. Chem. 272:7556-7564(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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